PUBLICATIONS

1 / Probing the catalytic mechanism and inhibition of SAMHD1 using the differential properties of Rp- and Sp-dNTPαS diastereomers

Morris E.R., Kunzelmann S., Caswell S.J., Purkiss A.G., Kelly G., Taylor I.A. Biochemistry (2021) 60(21):1682–1698

DOI: 10.1021/acs.biochem.0c00944

2 / Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis

Morris E.R., Caswell S.J., Kunzelmann S., Arnold L.H., Purkiss A.G., Kelly G., Taylor I.A. Nat. Commun. (2020) 11:3165

DOI: 10.1038/s41467-020-16983-2

3 / Positive selection in dNTPase SAMHD1 throughout mammalian evolution

Monit C., Morris E.R., Ruis C., Szafran B., Thiltgen G., Tsai M.-H.C., Mitchison N.A., Bishop K.N., Stoye J.P., Taylor I.A., Fassati A., Goldstein R.A. Proc. Natl. Acad. Sci. U. S. A. (2019) 116(37):18647-18654

DOI: 10.1073/pnas.1908755116

4 / The missing link: allostery and catalysis in the anti-viral protein SAMHD1

Morris E.R. & Taylor I.A. Biochem. Soc. Trans. (2019) 47(4):1013–1027

DOI: 10.1042/bst20180348

5 / Structural basis for DNA 3′-end processing by human tyrosylDNA phosphodiesterase 1

Flett F.J., Ruksenaite E., Armstrong L.A., Bharati S., Carloni R., Morris E.R., Mackay C.L., Interthal H., Richardson J.M. Nat. Commun. (2018) 9:24

DOI: 10.1038/s41467-017-02530-z

6 / A bend, flip and trap mechanism for transposon integration

Morris E.R., Grey H., McKenzie G., Jones A.C., Richardson J.M. eLife (2016) 5:e15537

DOI: 10.7554/elife.15537

7 / A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa

Kulkarni P.R., Jia T., Kuehne S.A., Kerkering T.M., Morris E.R., Searle M.S., Heeb S., Rao J., Kulkarni R.V. Nucl. Acids Res. (2014) 42(11):6811–6825

DOI: 10.1093/nar/gku309

8 / Structural basis of Mos1 transposase inhibition by the anti-retroviral drug Raltegravir

Wolkowicz U.M., Morris E.R., Robson M., Trubitsyna M., Richardson J.M. A.C.S. Chem. Biol. (2014) 9(3):743–751

DOI: 10.1021/cb400791u

9 / Biochemical characterization and comparison of two closely related active mariner transposases

Trubitsyna M., Morris E.R., Finnegan D.J., Richardson J.M. Biochemistry (2014) 53(4):682–689

DOI: 10.1021/bi401193w

10 / Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN

Morris E.R., Hall G., Li C., Heeb S., Kulkarni R.V., Lovelock L., Silistre H., Messina M., Cámara M., Emsley J., Williams P., Searle M.S. Structure (2013) 21(9):1659-1671

DOI: 10.1016/j.str.2013.07.007

11 / Overview of protein folding mechanisms: experimental and theoretical approaches to probing energy landscapes

Morris E.R. & Searle M.S. Curr. Protoc. Protein Sci. (2012) 68(1):28.2.1-28.2.22

DOI: 10.1002/0471140864.ps2802s68

Article@ResearchGate

12 / Exploring knotting mechanisms in protein folding

Mallam A.L., Morris E.R., Jackson S.E. Proc. Natl. Acad. Sci. U. S. A. (2008) 105(48):18740-18745

DOI: 10.1073/pnas.0806697105